With several countries worldwide now reporting cases, scientists from the UK, US and World Health Organisation are working on identifying a cause.
“The rising incidence of children with sudden onset hepatitis is unusual and worrying. The fact there have been eight so far in 2022, with less than a third of the way through, is clearly a concern. The UK Health Security Agency has advised that people observe normal hygiene measures such as thorough handwashing and disposing of tissues if they have a cold.
Federal health officials and the Alabama Department of Public Health are investigating nine cases of hepatitis in children 1 to 6 years old who were ...
This year, there have been four patients and two of those patients also had coronavirus, Fischer said. Amy Edwards, a pediatric infectious-disease specialist at University Hospitals Rainbow Babies & Children’s Hospital in Cleveland, said that with mild cases of hepatitis parents and children may not even know there is an issue and it will resolve itself. None of the children in the U.K., who were all under age 10, had been vaccinated against coronavirus, according to the U.K. Health Security Agency. They have also been ruled out in the U.K. children, authorities there said. After further investigation, the hospital identified four more cases, all of whom had liver injury and adenovirus infection. Hepatitis can be triggered by a variety of factors, from toxic chemicals to autoimmune disorders and viruses that cause chickenpox and the common cold. “If it’s a bad case, there will be symptoms.” Adenoviruses most commonly cause respiratory illnesses, but they can also cause inflammation of the stomach. North Carolina also had two cases in school-age children, neither of whom needed a liver transplant and subsequently recovered, STAT reported. Five children were admitted to a children’s hospital with significant liver injury, including some with acute liver failure. The children were from across the state and officials have found no epidemiological link connecting them. Several of the U.K. patients also had coronavirus infections, the WHO said.
108 children have tested positive for inflammatory liver condition in Britain · Scottish experts claim it could be caused by less social mixing in pandemic ...
Lab tests are also under way to determine if a chemical or toxin might be the cause. The UN health agency said that given the jump in cases and heightened surveillance, it is 'very likely' more cases will be detected before the cause of the outbreak is identified. When hepatitis is spread by a virus, it's usually caused by consuming food and drink contaminated with the faeces of an infected person or blood-to-blood or sexual contact. Professor Cooke told The i: 'There is going to be a group of children under the age of two who have not been exposed to the same number of viruses that they would have been exposed to normally.' When hepatitis is spread by a virus, it's usually caused by consuming food and drink contaminated with the faeces of an infected person or blood-to-blood or sexual contact. Covid lockdowns may be behind the mysterious spate of hepatitis cases in children because they reduced social mixing and weakened their immunity, experts claim
The leading hypothesis at present is that infection with an adenovirus, a virus normally associated with colds, may have triggered the liver inflammation in ...
Authorities in the U.K. have reported 77% of their cases have tested positive for adenovirus infection and Alabama reported last week that five of its nine cases tested positive for adenovirus 41. But the degree of it was the thing that was concerning to us.” There have been reports of hepatitis in immunocompromised children infected with adenovirus type 41, but it hasn’t previously been seen to cause liver disease in healthy children. The number of countries reporting these unusual cases of hepatitis continues to rise, with reports that France is investigating two suspected cases in Lyon and Israel is studying a dozen children who had unexplained cases of hepatitis over the past four months, two requiring liver transplants. While most of the children have made full recoveries, some have required liver transplants, including two in Alabama, eight in the United Kingdom, and one in Spain. To date, there have been no reports of deaths. The overall number of cases is small, but the outbreak is unusual.
Public Health Scotland epidemiologist Dr Kimberly Marsh said in the report that children could be 'immunologically naive' to the virus due to restrictions ...
Eight of the 108 cases have received a liver transplant. "We are also calling on parents and guardians, to be alert to the signs of hepatitis (including jaundice) and to contact a healthcare professional if they are concerned." The agencies investigating the cases are the UKHSA, Public Health Scotland, Public Health Wales and the Public Health Agency.
The alarm was first raised in Glasgow in late March, and cases have since been found in countries including the US, Denmark and Israel.
Usually, it is rare to see this many cases in a year. These kids have not been exposed to the viruses they would have been,” Prof Irving said. Alternatively, if adenovirus is the culprit for hepatitis in children that are otherwise well, we ought to look for other infections and environmental causes that could exacerbate adenoviral inflammation,” Dr Stamataki said. Since we relaxed those precautions in the UK, we’ve had much higher rates of viral infections. “I would not like to place a bet on what the cause will be – it’s really unusual. Since January, 108 children across the country have developed sudden onset hepatitis – or liver inflammation.
The number of cases of the liver disease among children under the age of 10 has risen to 108, and eight children in the UK have received a liver transplant.
None of the currently confirmed cases had been vaccinated, it said. There a five types of hepatitis caused by viruses, known as A, B, C, D and E, but none of the cases in seen in children this time seem to have been caused by these. Of the confirmed cases, 79 are in England, 14 are in Scotland and the remainder are in Wales and Northern Ireland. So far, eight children in the UK have received a liver transplant.
The advisory says Alabama health officials identified nine cases of hepatitis in children aged between one and six, who had also tested positive for adenovirus ...
It also recommended that adenovirus testing be carried out when the cause of a child’s infection isn’t clear. Start your Independent Premium subscription today. The advisory says Alabama health officials identified nine cases of hepatitis in children aged between one and six, who had also tested positive for adenovirus since October. All children were previously healthy and none had contracted Covid-19.
The number of cases of hepatitis among children under the age of 10 being investigated has risen to 108, health officials have confirmed.
The number of cases of hepatitis among children under the age of 10 being investigated has risen to 108, health officials have confirmed.
The UKHSA said it was also investigating whether there had been a change in the genome of the adenovirus. But the agency added it was "not usual to see this pattern of disease" from adenovirus, and it was also looking into other possible factors, such as another infection like Covid-19 or an environmental cause. The agency also said it is investigating the possible causes behind the spike in cases but there was no link to the Covid-19 vaccine as none of the children affected was known to have received a jab.
'Unusual and worrying': Child hepatitis cases reported worldwide - is your child at risk? · THE UK Health Security Agency (UKHSA) has issued an update on the ...
The expert continued: "The rising incidence of children with sudden onset hepatitis is unusual and worrying. The communicable disease is usually spurred by one of five pathogens. THE UK Health Security Agency (UKHSA) has issued an update on the rising prevalence of hepatitis cases among young children after cases were confirmed in several countries. Professor Deirdre Kelly, Professor of Paediatric Herpetology at the University of Birmingham, stressed that a high incidence of hepatitis among children is rare. In what experts are describing as an "unusual and worrying" occurrence, an increasing number of youngsters are undergoing liver transplants as a result of the virus. "If viral disease is suspected as the cause of liver injury, we need to establish if it is the virus or the immune system that is rapidly damaging the liver."
Health officials are seeing a spike in sudden onset hepatitis in children under 10 years old as eight kids in the UK have had a liver transplant - now, ...
None of the currently confirmed cases in the UK is known to have been vaccinated. "We are also calling on parents and guardians, to be alert to the signs of hepatitis (including jaundice) and to contact a healthcare professional if they are concerned." Cases of hepatitis in children are being investigated as more cases have been found in the UK, Europe and USA.
As health experts investigate the cause, here's what you need to know – including symptoms to watch out for.
Prof Kelly said that, for an unplanned liver transplant, the success rate is usually between 70 and 80 per cent, and the children can go on to live almost a normal life. Most of the children are also under five, so not yet eligible to receive a vaccine in the UK. It is recommended when the liver has stopped working properly and other treatments cannot help. The liver has an amazing ability to regenerate itself after an insult – generally within a few days or weeks things settle back down with this supportive treatment.” Usually, it is rare to see this many cases in a year. Five of the nine cases detected in Alabama were also infected.
U.S. health officials have sent out a nationwide alert warning doctors to be on the lookout for symptoms of unexplained hepatitis in kids, after clusters of ...
And Alabama state health officials said none of the nine cases there had any history of prior COVID-19 infection. Lab tests found that some of these children were infected with adenovirus type 41, which causes acute infection of the digestive system. In some instances, cases were so severe that children required liver transplants. The more common forms of the liver disease - hepatitis A, hepatitis B, and hepatitis C - were ruled out. The warning followed a CDC investigation with the Alabama Department of Public Health into a cluster of nine cases of hepatitis of unknown origin in previously healthy children ranging in age from 1 to 6-years old. U.S. health officials have sent out a nationwide alert warning doctors to be on the lookout for symptoms of unexplained hepatitis in kids, after clusters of mysterious cases in the US and UK.
Hepatitis C virus, illustration. Hepatitis C is most commonly spread by blood contact, A mystery hepatitis outbreak has affected 108 children in the UK (Photo: ...
“The rising incidence of children with sudden onset hepatitis is unusual and worrying. Dr Zania Stamataki, associate professor in viral immunology at the Centre for Liver and Gastrointestinal Research at the University of Birmingham, said: “Liver inflammation (known as hepatitis) caused by adenovirus is uncommon in the young, with the exception of immunocompromised children. “We are also calling on parents and guardians, to be alert to the signs of hepatitis (including jaundice) and to contact a healthcare professional if they are concerned.” Experts have called the recent hepatitis outbreak unusual, and there are concerns, but at the moment it is only affecting a minute number of children. There are multiple types of hepatitis (A to E, as well as alcoholic hepatitis and autoimmune hepatitis), some of which will pass without any serious problems, while others can be long-lasting (chronic) and cause scarring of the liver (cirrhosis), loss of liver function and, in some cases, liver cancer. The number of children in the UK confirmed to have been affected by a mystery hepatitis outbreak has risen to 108.
Lockdowns could also have had an impact, experts said. Professor Deirdre Kelly, Professor of Pediatric Hepatology at Birmingham Women's & Children's.
Professor Kelly said that for an unplanned liver transplant, the success rate is usually between 70 and 80% and children can go on to live almost normal lives. Professor Simon Taylor-Robinson, a hepatologist at Imperial College London, said: ‘Treatment is usually supportive – with hydration and temperature management – as the problem resolves normally. Most children are also under five and therefore not yet eligible to receive a vaccine in the UK.
The Centers for Disease Control and Prevention announced Thursday that the public health agency is looking into a cluster of hepatitis cases among children ...
Researchers at the CDC suspect that the adenovirus infections may have caused the pediatric hepatitis cases and are still working to find out more information. [It's] very unusual to see it in this pediatric population," Ashton added. The children have also tested positive for adenovirus infection, which most commonly causes respiratory illness, but depending on the type, can cause gastrointestinal infection in children.
Lola-Rose Raine was placed in an induced coma after suffering liver failure, and was saved after receiving a transplant from her father.
That's more than we would see normally in an average year in this age group and in children, and therefore when we see that we need to investigate and understand the cause. We have so far identified, in a significant proportion of these cases, about 77%, related to an adenovirus infection. Jane and Alan have been told their daughter's liver failure was caused by an adenovirus infection. "It was something neither of us wanted to see," she said. Lola-Rose was placed in an induced coma to give her body a chance of surviving potential multiple organ failure. Both parents volunteered to become liver transplant donors for their daughter but dad Alan was considered a safer match.
Three-year-old Lola-Rose Raine suffered acute liver failure after falling ill with hepatitis. She is one of 108 cases that have appeared in the UK since ...
Lola was sent for a CT scan to have a closer look, and Jane was told she may need surgery. They found a blood clot in the portal vein - a blood vessel that carries blood from the gastrointestinal tract, gallbladder, pancreas and spleen to the liver. The nurse in charge called Jane and told her to come in from the house. On the morning of March 28 they tested Lola's levels and they were 5.3. That was worse than before, but to be expected. They carried out a physical and mental assessment, and determined I was actually a relation to Lola and hadn't been forced or bribed into being a donor. Jane knew that she was a blood match for Lola, being in the same blood group. She had a feeding tube up her nose and a monitor attached to her forehead measuring the levels of oxygen in the brain. A filter was attached to pull blood from her body, filter the ammonia out and send it back. But this meant that her blood was cold by the time it got back to her body, so she had to have a heated blanket over her constantly. We tried all weekend, and finally managed to start the process the morning of Tuesday 29. Her liver was now in complete failure and was affecting other parts in the body. I laid on the floor bedside her bed until she fell asleep to make sure she was okay.
Under-fives are falling ill but the scale of the outbreak, combined with a complete absence of the 'usual suspects', is baffling scientists.
So far eight children in the UK have been through this process, with one on a waiting list. But it is equally possible that the cases start to fade away, possibly without us ever knowing why.” While the case definition applies to children under 10, most in the UK are actually younger than five, so not yet eligible to receive a vaccine. “It’s hugely important to have an open mind that an adenovirus might not be the only factor here,” she said. One day she was a bubbly child, then she was admitted to hospital and a week and a half later she was in a coma with acute liver failure,” he said. You may see that they start developing a yellow tinge, usually it starts from the eyes and then gradually spreads over the skin.” In the Eurosurveillance report describing Scotland’s early cases, published on April 14, no specific characteristics stand out – just over half were female, all were white and there was not a “discernible geographic pattern”. “But this year is a big jump. In a sure sign of liver damage their skin was jaundiced, the yellow tinge gradually spreading from their eyes. In up to 20 per cent of cases, no cause is identified. She is currently recovering from an urgent transplant at King’s College Hospital in London, after Mr Raine donated part of his liver to save her life two weeks ago. In late March, doctors at Glasgow’s Royal Hospital for Children already had a sinking feeling that something was wrong.
Health authorities around the world are investigating a mysterious increase in severe cases of hepatitis - inflammation of the liver – in young children.
Register now for FREE unlimited access to Reuters.com Register now for FREE unlimited access to Reuters.com Register now for FREE unlimited access to Reuters.com Public health alerts in the United States and Europe have asked doctors to be on the lookout for the condition, and to test children for adenovirus if they suspect hepatitis.
Three-year-old Lola-Rose Raine suffered acute liver failure after falling ill with hepatitis.
Lola was sent for a CT scan to have a closer look, and Jane was told she may need surgery. They found a blood clot in the portal vein - a blood vessel that carries blood from the gastrointestinal tract, gallbladder, pancreas and spleen to the liver. The nurse in charge called Jane and told her to come in from the house. On the morning of March 28 they tested Lola's levels and they were 5.3. That was worse than before, but to be expected. They carried out a physical and mental assessment, and determined I was actually a relation to Lola and hadn't been forced or bribed into being a donor. Jane knew that she was a blood match for Lola, being in the same blood group. She had a feeding tube up her nose and a monitor attached to her forehead measuring the levels of oxygen in the brain. A filter was attached to pull blood from her body, filter the ammonia out and send it back. But this meant that her blood was cold by the time it got back to her body, so she had to have a heated blanket over her constantly. But she had to be on the urgent list for three days before we could start this process. Her liver was now in complete failure and was affecting other parts in the body. I laid on the floor bedside her bed until she fell asleep to make sure she was okay.
Hepatitis is inflammation of the liver. Adenoviruses are DNA viruses that commonly infect the respiratory system. Doctors who encounter pediatric hepatitis ...
Two of them needed liver transplants last year, The Post said. “The investigation, including information from patient samples and surveillance systems, continues to point towards a link to adenovirus infection. Two cases have been detected in North Carolina, NBC news reported.
The CDC issued a health advisory over a severe outbreak of hepatitis in children, potentially linked to adenovirus. Cases in the U.S. and Europe cause ...
In short, Dr. Bucuvalas says it’s important for healthcare professionals to work collaboratively and continue to report cases. The CDC is working with healthcare professionals to investigate the cluster of diagnoses and the potential link to adenovirus (common double-stranded DNA viruses that can cause an array of symptoms). This may have always been here and we never noticed it before,” he suggests. According to the CDC statement, all children were previously healthy and none had COVID-19. He notes that there is no consensus at this time as to what is causing this outbreak. After more research, the Alabama hospital identified four more children with hepatitis and adenovirus infections from October 2021 through February 2022.